The only difference is the color. HX5810 is more bluish. Sonic care Flexcare Essence HX5810 Toothbrush Handle fits Essence 5000 HX5300 HX5310 HX5350 HX5351 HX5451 HX5500 HX5700 HX5754 HX5800 HX5810 HX5600 HX5610 HX5620 HX2630 5300 5310 5500 5700 5750.